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Article

Human IgG2 Antibodies Display Disulfide-mediated Structural Isoforms

14 Mar 2008

Abstract excerpt

In this work, we present studies of the covalent structure of human IgG2 molecules. Detailed analysis showed that recombinant human IgG2 monoclonal antibody could be partially resolved into structurally distinct forms caused by multiple disulfide bond structures. In addition to the presently accepted structure for the human IgG2 subclass, we also found major structures that differ from those documented in the...

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PMID: 18339624
DOI: 10.1074/jbc.m709987200

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