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Article

Immortalization and characterization of rat microglial cells.

Neuropathology and applied neurobiology - 1 Aug 1995

McLaurin J, Almazan G, Williams K, Antel J P

Abstract excerpt

Microglial cell lines from rat brain were established by transfer of a temperature sensitive simian virus 40 large tumour antigen by means of a retrovirus. Four weeks after infection, colonies were generated in the presence of neomycin and granulocyte-macrophage colony stimulating factor (GM-CSF), and subsequently subcloned. Both bulk cell lines and clones proliferate actively at 33 degrees C, whereas the rate of...

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PMID: 7494598
DOI: 10.1111/j.1365-2990.1995.tb01064.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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