Article
Biological characterization of nef in long-term survivors of human immunodeficiency virus type 1 infection.
Journal of virology - 1 Dec 1995
Huang Y, Zhang L, Ho D D
Abstract excerpt
We have previously shown that there were no gross deletions or obvious sequence abnormalities within nef of human immunodeficiency virus type 1 (HIV-1) in the 10 long-term survivors studied (Y. Huang, L. Zhang, and D. D. Ho, J. Virol. 69:93-100, 1995). Here we extend our study to examine these nef alleles in a functional context. Using a new technique, termed site-directed gene replacement, we have precisely...
Topics
- Acquired Immunodeficiency Syndrome
- Alleles
- Amino Acid Sequence
- Cells, Cultured
- Chimera
- Follow-Up Studies
- Gene Deletion
- Gene Products, nef
- Genes, nef
- HIV Seropositivity
- HIV-1