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Article

Inefficient enhancement of viral infectivity and CD4 downregulation by human immunodeficiency virus type 1 Nef from Japanese long-term nonprogressors.

Journal of virology - 1 Jun 2002

Tobiume Minoru, Takahoko Mikako, Yamada Takeshi, Tatsumi Masashi, Iwamoto Aikichi, Matsuda Michiyuki

Abstract excerpt

It has been reported that patients infected with nef-defective human immunodeficiency virus type 1 (HIV-1) do not progress to AIDS; however, mutations that abrogate Nef expression are not common in long-term nonprogressors (LTNPs). We postulated that Nef function might be impaired in LTNPs, irrespective of the presence or absence of detectable amino acid sequence anomalies. To challenge this hypothesis we...

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Source

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Identifiers

PMID: 12021328
DOI: 10.1128/jvi.76.12.5959-5965.2002
PMCID: PMC136235

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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