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Article

CRKL Links p210BCR/ABL with Paxillin in Chronic Myelogenous Leukemia Cells

1 Dec 1995

Abstract excerpt

The Philadelphia chromosome translocation generates a chimeric oncogene, BCR/ABL, which causes chronic myelogenous leukemia (CML). In primary neutrophils from patients with CML, the major novel tyrosine-phosphorylated protein is CRKL, an SH2-SH3-SH3 linker protein which has an overall homology of 60% to CRK, the human homologue of the v-crk oncogene product. Anti-CRKL immunoprecipitates from CML cells, but not...

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PMID: 7493940
DOI: 10.1074/jbc.270.49.29145

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CRKL Links p210BCR/ABL with Paxillin in Chronic Myelogenous Leukemia CellsPMID 7493940Read ↗

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