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Article

Crkl enhances leukemogenesis in BCR/ABL P190 transgenic mice.

Cancer research - 15 Feb 2001

Hemmeryckx B, van Wijk A, Reichert A, Kaartinen V, de Jong R, Pattengale P K, Gonzalez-Gomez I, Groffen J, Heisterkamp N

Abstract excerpt

The adapter protein Crkl has been implicated in the abnormal signal transduction pathways activated by the Bcr/Abl oncoprotein, which causes Philadelphia-positive leukemias in humans. To investigate the role of Crkl in tumorigenesis, we have generated transgenic mice that express human Crkl from...

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Share to Adaptor Proteins, Signal Transducing
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11245441

Genes

BCR
CRKL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-11245441-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

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Crkl enhances leukemogenesis in BCR/ABL P190 transgenic mice.PMID 11245441Read ↗

BCR/ABL P190 transgenic mice develop leukemia in the absence of Crkl.Semantic proximity Read ↗

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The CRKL Adaptor Protein Transforms Fibroblasts and Functions in Transformation by the BCR-ABL OncogeneSemantic proximity Read ↗

Reduced oncogenicity of p190 Bcr/Abl F-actin-binding domain mutants.Semantic proximity Read ↗

Crk and CrkL as Therapeutic Targets for Cancer TreatmentSemantic proximity Read ↗

p130CAS Forms a Signaling Complex with the Adapter Protein CRKL in Hematopoietic Cells Transformed by the BCR/ABL OncogeneSemantic proximity Read ↗

Models of Crk Adaptor Proteins in CancerSemantic proximity Read ↗

Involvement of the adapter protein CRKL in integrin-mediated adhesion.Semantic proximity Read ↗

Development of Acute Lymphoblastic Leukemia and Myeloproliferative Disorder in Transgenic Mice Expressing p210bcr/abl: A Novel Transgenic Model for Human Ph1-Positive LeukemiasSemantic proximity Read ↗

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Generation of rac3 null mutant mice: role of Rac3 in Bcr/Abl-caused lymphoblastic leukemia.Semantic proximity Read ↗

β3 integrin-EGF receptor cross-talk activates p190RhoGAP in mouse mammary gland epithelial cells.Semantic proximity Read ↗

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