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Article

Crkl enhances leukemogenesis in BCR/ABL P190 transgenic mice.

Cancer research - 15 Feb 2001

Hemmeryckx B, van Wijk A, Reichert A, Kaartinen V, de Jong R, Pattengale P K, Gonzalez-Gomez I, Groffen J, Heisterkamp N

Abstract excerpt

The adapter protein Crkl has been implicated in the abnormal signal transduction pathways activated by the Bcr/Abl oncoprotein, which causes Philadelphia-positive leukemias in humans. To investigate the role of Crkl in tumorigenesis, we have generated transgenic mice that express human Crkl from the CRKL promoter. Western blot analysis showed a 4-6-fold overexpression of transgenic Crkl above endogenous crkl in...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11245441

Genes

BCR
CRKL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Crkl enhances leukemogenesis in BCR/ABL P190 transgenic mice.PMID 11245441Read ↗

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