Selective damage to the active X chromosome by camptothecin and amsacrine as determined by an allele-specific alkaline unwinding assay.

doi:10.1016/0006-2952(95)00247-w

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Article

Selective damage to the active X chromosome by camptothecin and amsacrine as determined by an allele-specific alkaline unwinding assay.

Biochemical pharmacology - 12 Oct 1995

Austin M J, Bunch R T, Povirk L F

Abstract excerpt

Previous studies with MCF-7 cells demonstrated that several agents induce greater strand breakage in active genes than in nontranscribed centromeric regions. To better assess the effects of gene activity and inactivity, an allele-specific DNA strand break assay was developed, which allowed direct...

Topics

Alleles
Amsacrine
Antineoplastic Agents, Phytogenic
Base Sequence
Camptothecin
Cell Line, Transformed
DNA
DNA Damage
Genetic Techniques
Glucosephosphate Dehydrogenase
Humans
Hydrogen-Ion Concentration
Lymphocytes
Molecular Sequence Data
X Chromosome

Source

Open in PubMed

Identifiers

PMID: 7488252
DOI: 10.1016/0006-2952(95)00247-w

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7488252-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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