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Article

New system based on site-directed mutagenesis for highly accurate comparison of resistance levels conferred by SHV beta-lactamases.

Antimicrobial agents and chemotherapy - 1 Aug 1995

Nüesch-Inderbinen M T, Hächler H, Kayser F H

Abstract excerpt

We developed a system based on site-directed mutagenesis that allows a precise comparison of SHV enzymes under isogenic conditions. In addition, the influences of two different, naturally occurring promoters were examined for each SHV derivative. The system comprised two separately cloned DNA fragments, each the size of 3.6 kb. Both fragments encoded an SHV gene originating from clinical isolates but with...

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Identifiers

PMID: 7486909
DOI: 10.1128/AAC.39.8.1726
PMCID: PMC162816

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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