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Article

Different promoters of SHV-2 and SHV-2a beta-lactamase lead to diverse levels of cefotaxime resistance in their bacterial producers.

Journal of general microbiology - 1 Jul 1991

Podbielski A, Schönling J, Melzer B, Haase G

Abstract excerpt

Clinical Klebsiella pneumoniae isolates as well as Escherichia coli transformants producing the beta-lactamases SHV-2 or SHV-2a demonstrate MIC values for cefotaxime of 4 mg l-1 or 64 to greater than 128 mg l-1, respectively. The beta-lactamases differ by one possibly insignificant amino acid exc...

Topics

Base Sequence
Blotting, Northern
Cefotaxime
Cloning, Molecular
Drug Resistance, Microbial
Escherichia coli
Genes, Bacterial
Klebsiella pneumoniae
Molecular Sequence Data
Mutation
Oligodeoxyribonucleotides

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymerase Chain Reaction

Promoter Regions, Genetic

Sequence Alignment

Single-Strand Specific DNA and RNA Endonucleases

beta-Lactamases

Source

Identifiers

PMID: 1955859
DOI: 10.1099/00221287-137-7-1667

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1955859-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Different promoters of SHV-2 and SHV-2a beta-lactamase lead to diverse levels of cefotaxime resistance in their bacterial producers.PMID 1955859Read ↗

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Genes encoding TEM-4, SHV-2, and CTX-M-10 extended-spectrum beta-lactamases are carried by multiple Klebsiella pneumoniae clones in a single hospital (Madrid, 1989 to 2000).Semantic proximity Read ↗

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