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Article

Human immunodeficiency virus envelope V1 and V2 regions influence replication efficiency in macrophages by affecting virus spread.

Virology - 20 Oct 1995

Toohey K, Wehrly K, Nishio J, Perryman S, Chesebro B

Abstract excerpt

The V3 hypervariable region of the HIV-1 envelope protein is a major determinant of viral tropism for macrophages. However, the replication of macrophage-tropic HIV-1 strains varies considerably in macrophages, and this variability has been linked to the V1 and V2 envelope regions. In the present study, recombinant HIV clones were generated by inserting V1 and V2 sequences from the Ba-L HIV isolate, which has a...

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Identifiers

PMID: 7483281
DOI: 10.1006/viro.1995.1547

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