Article
Human immunodeficiency virus envelope V1 and V2 regions influence replication efficiency in macrophages by affecting virus spread.
Virology - 20 Oct 1995
Toohey K, Wehrly K, Nishio J, Perryman S, Chesebro B
Abstract excerpt
The V3 hypervariable region of the HIV-1 envelope protein is a major determinant of viral tropism for macrophages. However, the replication of macrophage-tropic HIV-1 strains varies considerably in macrophages, and this variability has been linked to the V1 and V2 envelope regions. In the present...
Topics
- Amino Acid Sequence
- Base Sequence
- CD4-Positive T-Lymphocytes
- Cells, Cultured
- DNA Primers
- DNA, Viral
- Enzyme-Linked Immunosorbent Assay
- Genes, env
- HIV Core Protein p24
- HIV Envelope Protein gp120
- HIV-1
- HeLa Cells
- Humans
- Immunoenzyme Techniques
- Macrophages
- Molecular Sequence Data
- Phenotype
- Recombinant Fusion Proteins