UREB1, a tyrosine phosphorylated nuclear protein, inhibits p53 transactivation.

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Article

UREB1, a tyrosine phosphorylated nuclear protein, inhibits p53 transactivation.

Oncogene - 16 Nov 1995

Gu J, Dubner R, Fornace A J, Iadarola M J

Abstract excerpt

Tumor suppressor p53 is a transcription activator that upregulates target genes containing the p53 binding site. UREB1, a DNA binding protein that is tyrosine phosphorylated in vivo, shares a significant homology with the human papilloma virus E6 associated protein (E6-AP). E6-AP forms a ternary complex with E6 and p53 and participates in the ubiquitination of p53. Based on the homology with E6-AP, but taking...

Topics

Amino Acid Sequence
Animals
Binding Sites
DNA-Binding Proteins
Genes, p53
Humans
Mice
Molecular Sequence Data
Mutation
Nuclear Proteins
Phosphoproteins
Phosphorylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Sequence Homology, Amino Acid

Transcriptional Activation

Transfection

Tumor Suppressor Protein p53

Tumor Suppressor Proteins

Tyrosine

Source

Open in PubMed

Identifiers

PMID: 7478539

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7478539-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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