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Article

UREB1, a tyrosine phosphorylated nuclear protein, inhibits p53 transactivation.

Oncogene - 16 Nov 1995

Gu J, Dubner R, Fornace A J, Iadarola M J

Abstract excerpt

Tumor suppressor p53 is a transcription activator that upregulates target genes containing the p53 binding site. UREB1, a DNA binding protein that is tyrosine phosphorylated in vivo, shares a significant homology with the human papilloma virus E6 associated protein (E6-AP). E6-AP forms a ternary complex with E6 and p53 and participates in the ubiquitination of p53. Based on the homology with E6-AP, but taking...

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PMID: 7478539

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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