Article
Ultraviolet B irradiation-induced G2 cell cycle arrest in human keratinocytes by inhibitory phosphorylation of the cdc2 cell cycle kinase.
Oncogene - 16 Nov 1995
Herzinger T, Funk J O, Hillmer K, Eick D, Wolf D A, Kind P
Abstract excerpt
In response to genotoxic stress, cell cycle progression can be arrested at certain checkpoints which serve to maintain genomic integrity. We have investigated the mechanism of ultraviolet B (UVB) irradiation-induced cell cycle arrest in normal human keratinocytes and in the HaCaT keratinocyte cell line which carries mutant p53 tumour suppressor protein. While only normal keratinocytes showed a delay in G1...
Topics
- CDC2 Protein Kinase
- Cell Cycle
- Cells, Cultured
- Cyclins
- Dose-Response Relationship, Radiation
- G2 Phase
- Humans
- Keratinocytes
- Mutation
- Phosphorylation
- Tumor Suppressor Protein p53