New mutant rabbit strain with hypercholesterolemia and atherosclerotic lesions produced by serial inbreeding.

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

New mutant rabbit strain with hypercholesterolemia and atherosclerotic lesions produced by serial inbreeding.

Laboratory animal science - 1 Aug 1995

Kurosawa T, Kusanagi M, Yamasaki Y, Senga Y, Yamamoto T

Abstract excerpt

We have investigated the characteristics of the Kurosawa and Kusanagi hypercholesterolemic (KHC) rabbit, a strain manifesting inherited and persistent hypercholesterolemia and produced by inbreeding from mutants discovered in 1985. These KHC rabbits had abnormally high serum cholesterol, triglyceride, and phospholipid concentrations 8 to 10 times greater than the concentrations in clinically normal Japanese white...

Topics

Animals
Aorta
Arteriosclerosis
Base Sequence
Cholesterol
Cholesterol, HDL
Coronary Vessels
Disease Models, Animal
Gene Deletion
Hypercholesterolemia
Inbreeding

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Lipoproteins, HDL

Lipoproteins, LDL

Molecular Sequence Data

Mutation

Phospholipids

RNA, Messenger

Rabbits

Source

Open in PubMed

Identifiers

PMID: 7474877

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7474877-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

New mutant rabbit strain with hypercholesterolemia and atherosclerotic lesions produced by serial inbreeding.PMID 7474877Read ↗

Spontaneous severe hypercholesterolemia and atherosclerosis lesions in rabbits with deficiency of low-density lipoprotein receptor (LDLR) on exon 7Semantic proximity Read ↗

Hyperlipidemia-associated gene variations and expression patterns revealed by whole-genome and transcriptome sequencing of rabbit models.Semantic proximity Read ↗

ApoE knockout rabbits: A novel model for the study of human hyperlipidemia.Semantic proximity Read ↗

The laboratory rabbit: an animal model of atherosclerosis researchSemantic proximity Read ↗

Principles and Applications of Rabbit Models for Atherosclerosis ResearchSemantic proximity Read ↗

Four strains of spontaneously hyperlipidemic (SHL) mice: phenotypic distinctions determined by genetic backgrounds.Semantic proximity Read ↗

A genetic model for control of hypertriglyceridemia and apolipoprotein B levels in the Johns Hopkins colony of St. Thomas Hospital rabbits.Semantic proximity Read ↗

Control of variance in experimental studies of hyperlipidemia using the WHHL rabbit.Semantic proximity Read ↗

High incidence of spontaneous cataracts in aging laboratory rabbits of an inbred strain.Semantic proximity Read ↗

Pathologic findings in rabbit models of hereditary hypertriglyceridemia and hereditary postprandial hypertriglyceridemia.Semantic proximity Read ↗

In vivo gene therapy for hyperlipidemia: phenotypic correction in Watanabe rabbits by hepatic delivery of the rabbit LDL receptor gene.Semantic proximity Read ↗

Quantitative trait locus analysis of plasma cholesterol and triglyceride levels in C57BL/6J x RR F2 mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.