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Article

Control of variance in experimental studies of hyperlipidemia using the WHHL rabbit.

Journal of lipid research - 1 Jul 1991

Donnelly T M, Kelsey S F, Levine D M, Parker T S

Abstract excerpt

Between-animal variability has frustrated many experimental studies in outbred animal models of human disease. Variability that arises from genetic heterozygosity can be minimized by use of experimental designs that match littermates (polyzygotic twins) across control and treatment groups. Poor breeding vigor has prevented use of this experimental design in the WHHL rabbit model of hyperlipidemia and...

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PMID: 1940633

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