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Article

Control of variance in experimental studies of hyperlipidemia using the WHHL rabbit.

Journal of lipid research - 1 Jul 1991

Donnelly T M, Kelsey S F, Levine D M, Parker T S

Abstract excerpt

Between-animal variability has frustrated many experimental studies in outbred animal models of human disease. Variability that arises from genetic heterozygosity can be minimized by use of experimental designs that match littermates (polyzygotic twins) across control and treatment groups. Poor b...

Topics

Animals
Breeding
Cholesterol
Female
Genetic Variation
Heterozygote
Homozygote
Hyperlipidemias
Litter Size
Male
Rabbits
Reproduction
Triglycerides

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PMID: 1940633

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1940633-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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