Genetic heterogeneity in primary ankylosing spondylitis.

Abstract excerpt

We studied 115 white patients suffering from primary ankylosing spondylitis (AS). HLA-B27 was present in 105 patients (92%) and 8% of controls (pc < 0.001). Four of the 10 B27 negative patients were noted to possess HLA-Bw16 (40%), compared to 3.09% of 444 B27 negative controls (pc < 0.014). These findings suggest the existence of genetic heterogeneity in primary AS. Moreover, since Bw16 is also known to be...

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