Article
Evidence against a generalized membrane defect in dystrophic mice platelets.
Muscle & nerve - 1 Jan 2000
Mizobe F, Livett B G
Abstract excerpt
The response of the membrane-bound enzyme AChE to changes in temperatures was investigated to test the applicability of the "generalized membrane defect" hypothesis proposed for human myotonic and Duchenne muscular dystrophies to the two forms of muscular dystrophy expressed in mice. For intact platelets from homozygous normal and dystrophic mice of both strains, a break (Tc) occurred in the Arrhenius plot of...
Topics
- Acetylcholinesterase
- Animals
- Blood Platelets
- Cell Membrane
- Genotype
- Kinetics
- Mice
- Mice, Inbred Strains
- Muscular Dystrophy, Animal
- Temperature