Article
Hemolytic anemias due to hemoglobinopathies.
Molecular aspects of medicine - 1 Apr 1996
Poyart C, Wajcman H
Abstract excerpt
Hemoglobinopathies responsible for hemolytic anemias may be divided into two groups. The first one corresponds to thalassemias and the second to the presence of a structurally abnormal hemoglobin (Hb). In thalassemia, the primary biochemical abnormality is a quantitative defect in the biosynthesis of one type of Hb chain. This defect leads to an overall deficit of Hb accumulation in the erythrocyte (hypochromia)...
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