Article
In vivo cytogenetic effects of the cooked-food-related mutagens Trp-P-2 and IQ in mouse bone marrow.
Mutation research - 1 Jan 2000
Minkler J L, Carrano A V
Abstract excerpt
Sister-chromatid exchange and chromosomal aberrations were measured in vivo in mouse bone marrow following intraperitoneal injection of the cooked food mutagens, Trp-P-2 and IQ. Trp-P-2 produced a significant positive dose response for both endpoints while IQ produced only a weak but significant sister-chromatid exchange response. The relative potency of these two chemicals is similar to that seen in mammalian...
Topics
- Animals
- Bone Marrow
- Carbolines
- Chromosome Aberrations
- Crossing Over, Genetic
- Cyclophosphamide
- Food
- Hot Temperature
- Indoles
- Male
- Mice
- Mice, Inbred C57BL