[The mechanism of antigenic shift and drift of human influenza virus].

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Article

[The mechanism of antigenic shift and drift of human influenza virus].

Nihon rinsho. Japanese journal of clinical medicine - 1 Nov 2003

Nakajima Katsuhisa

Abstract excerpt

Influenza virus has a remarkable ability in escaping host defense mechanisms by altering its the antigenic character. The molecular mechanisms by which viruses alter their antigenic character form an important subject of study since they ultimately control epidemics of influenza. 1) We showed how the 1993/1994 antigenic variant viruses appeared from the 1991 virus by analyzing human sera with a chimeric protein...

Topics

Amino Acid Sequence
Animals
Antigenic Variation
Antigens, Viral
Evolution, Molecular
Genetic Drift
Hemagglutinins, Viral
Humans
Influenza A virus
Influenza, Human
Mutation

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PMID: 14619428

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