Article
Mutagenicity of hexachlorobutadiene, perchlorobutenoic acid and perchlorobutenoic acid chloride.
Mutation research - 1 Jan 2000
Reichert D, Neudecker T, Schütz S
Abstract excerpt
Hexachloro(1,3)butadiene (HCBD) is a well known environmental contaminant. The nephrocarcinogenic potential of HCBD has been shown in long-term studies with rats. Experiments were performed to assist in determining whether this effect is mediated by epigenetic or genotoxic mechanisms and to compare the mutagenic properties of HCBD with those of its monooxidation products, perchloro-3-butenoic acid (PCBA) and...
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