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Tigecycline-Rifampicin Restrains Resistance Development in Carbapenem-Resistant Klebsiella pneumoniae.

ACS infectious diseases - 13 Oct 2023

Shi Shiyi, Xu Mengxin, Zhao Yining, Feng Luozhu, Liu Qi, Yao Zhuocheng, Sun Yao, Zhou Tieli, Ye Jianzhong

Abstract excerpt

The goal of this study was to clarify the synergistic antibacterial activity of the combination of tigecycline (TGC) and rifampicin (RIF). Additionally, the study sought to investigate the impact of this combination on the development of mutational resistance and to assess its efficacy in an in vivo model using Galleria mellonella. Through a checkerboard test, we found that the combination of TGC and RIF showed...

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PMID: 37669401
DOI: 10.1021/acsinfecdis.3c00186

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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