Genetic instability in the human population: A working hypothesis1,2

Abstract excerpt

In several rare syndromes, genetic instability, expressed as chromosome instability, is known. Patients with these syndromes are predisposed to cancer. Evidence has been accumulating to show that chromosome instability occurs in some other diseases also, though the frequency was not as high. Genetic instability may induce mutational events in a chromosome (second step) whose homolog has a congenital defect...

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