Article
Cis-acting transmission of genomic instability.
Mutation research - 2 Dec 2004
Pongsaensook Punnajit, Ritter Linda E, Parks Karyn K, Grosovsky Andrew J
Abstract excerpt
Genomic instability is a highly pleiotropic phenotype, which may reflect a variety of underlying mechanisms. Destabilization has been shown in some cases to involve mutational alteration or inactivation of trans-acting cellular factors, for example, p53 or mismatch repair functions. However, aspects of instability are not well explained by mutational inactivation of trans-acting factors, and other epigenetic and...
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