Article
Automodulation of genes: a proposed mechanism for persisting effects of drugs and hormones in mammals.
Neurobehavioral toxicology and teratology - 1 Jan 2000
Campbell J H, Zimmermann E G
Abstract excerpt
We propose that hormone receptors are encoded by specially organized genetic elements that have the capacity to manipulate their own structure with enzymes in controlled ways. An automodulating element codes for a cell surface receptor protein. When this detector molecule is stimulated by its ligand (either by a natural hormone or a drug analog), a signal is transmitted back to the nucleus to activate an enzyme...
Topics
- Animals
- DNA
- Gene Expression Regulation
- Genetic Engineering
- Genetic Variation
- Phenotype
- Rabbits
- Receptors, Cell Surface
- Receptors, Drug