Automodulation of genes: a proposed mechanism for persisting effects of drugs and hormones in mammals.

Article

Automodulation of genes: a proposed mechanism for persisting effects of drugs and hormones in mammals.

Neurobehavioral toxicology and teratology - 1 Jan 2000

Campbell J H, Zimmermann E G

Abstract excerpt

We propose that hormone receptors are encoded by specially organized genetic elements that have the capacity to manipulate their own structure with enzymes in controlled ways. An automodulating element codes for a cell surface receptor protein. When this detector molecule is stimulated by its ligand (either by a natural hormone or a drug analog), a signal is transmitted back to the nucleus to activate an enzyme...

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