Article
Brain NaK-ATPases in mice differentially sensitive to alcohols.
Alcoholism, clinical and experimental research - 1 Jan 2000
Marks M J, Smolen A, Collins A C
Abstract excerpt
The isozymes of NaK-ATPase were studied in the particulate fraction of homogenates prepared from cortex of LS and SS mice, two lines of mice that have been selectively bred for differential response to ethanol. In addition to a ouabain-insensitive Mg-ATPase, ouabain dose-response curves have suggested the presence, in brain, of two NaK-ATPase activities with different sensitivities to ouabain. These are...
Topics
- Animals
- Brain
- Electrophoresis, Polyacrylamide Gel
- Ethanol
- Genotype
- Hydroxymercuribenzoates
- Isoenzymes
- Male
- Mice
- Mice, Inbred Strains
- Molecular Weight
- Ouabain