Article
Effect of chronic ethanol treatment and selective breeding for sensitivity to ethanol on calcium release induced by inositol trisphosphate or ethanol from brain and liver microsomes.
Alcoholism, clinical and experimental research - 1 Mar 1991
Daniell L C, Harris R A
Abstract excerpt
Our previous work showed that ethanol increases the resting intracellular free calcium concentration (CAi) in synaptosomes and releases calcium from an inositol trisphosphate (IP3)-insensitive calcium store of brain microsomes. In this report, we investigated the effects of chronic ethanol treatment and selective breeding for hypnotic sensitivity to ethanol on IP3 and ethanol-stimulated calcium release from brain...
Topics
- Alcohol Drinking
- Alcoholism
- Animals
- Arousal
- Brain
- Calcium
- Ethanol
- Inositol 1,4,5-Trisphosphate
- Male
- Mice
- Microsomes
- Microsomes, Liver