Article
Genetically determined alcohol preference and cyclic AMP binding proteins in mouse brain.
Alcoholism, clinical and experimental research - 1 Apr 1990
Beeker K R, Lee R C, Phung H M, Smith C P, Pennington S N
Abstract excerpt
Free-choice consumption of alcohol by mice with differing phenotypic alcohol preferences caused uniformly large decreases in brain cyclic AMP-dependent protein kinase activity toward an exogenous substrate (histone 2b) but the effect of alcohol on brain cyclic AMP binding activity was strain-specific. Furthermore, particulate kinase phosphorylating activity toward an endogenous protein (kinase regulatory subunit,...
Topics
- Alcoholism
- Animals
- Brain
- Carrier Proteins
- Cyclic AMP
- Cyclic AMP Receptor Protein
- Male
- Mice
- Mice, Inbred Strains
- Phenotype
- Prostaglandins E
- Protein Kinases