Article
A mathematic model for relating the drug sensitivity of tumors to their spontaneous mutation rate.
Cancer treatment reports - 1 Jan 2000
Goldie J H, Coldman A J
Abstract excerpt
A mathematic model has been developed relating the drug sensitivity of a tumor to its own spontaneous mutation rate towards phenotypic drug resistance. The proportion as well as the absolute numbers of resistant cells will increase with time and the fraction of resistant cells within tumor colonies of the same size with vary depending on whether mutation occurs as an early or late event. Analysis of the model...
Topics
- Antineoplastic Agents
- Drug Resistance
- Humans
- Mathematics
- Models, Biological
- Mutation
- Neoplasms
- Phenotype
- Probability
- Time Factors