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Article

Genetic links between female reproductive milestones and major depressive disorder: evidence from a common genetic factor model.

Archives of women's mental health - 22 Sept 2026

Ma Xiaoying, Chen Yang, Wang Qiang

Abstract excerpt

BACKGROUND: Major depressive disorder (MDD) is more prevalent in women and has been linked to female reproductive timing. However, the genetic mechanisms underlying these associations remain unclear. Reproductive milestones are temporally structured and biologically interrelated, suggesting a shared genetic architecture that may influence MDD susceptibility. METHODS: Using large-scale genome-wide association...

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Topics

Humans
Female
Major Depressive Disorder
Genome-Wide Association Study
Linkage Disequilibrium
Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

Mendelian Randomization Analysis

Menarche

Reproduction

Adult

Source

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Identifiers

PMID: 42771084
DOI: 10.1007/s00737-026-01759-2
PMCID: PMC13597589

Genes

CFI

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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