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Article

The relationship between vitamin D levels and depression: a genetically informed study.

Nutrition journal - 10 Oct 2025

Lyu Honggang, Kang Lijun, Gong Qian, Xie Xin-Hui, Ma Simeng, Yao Lihua, Chen Mian-Mian, Zhang Lingfeng, Yu Hao, Wang Xubo, Wang Chao, Liu Zhongchun

Abstract excerpt

BACKGROUND: Low vitamin D (vitD) levels are consistently associated with an increased risk of depression. However, the biological mechanisms underlying this relationship and potential shared genetic overlap remain elusive. METHODS: We investigated the genetic overlap and causal relationships between depression (N = 589,356) and vitD levels (N = 417,580) using genome-wide association study (GWAS) summary...

Read the complete abstract on PubMed

Topics

Humans
Genome-Wide Association Study
Depression
Vitamin D
Mendelian Randomization Analysis
Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Vitamin D Deficiency

Female

Multifactorial Inheritance

Genetic Predisposition to Disease

Male

Source

Open in PubMed Open full text

Identifiers

PMID: 41074179
DOI: 10.1186/s12937-025-01199-1
PMCID: PMC12512799

Genes

CTNND1
ESR1
FURIN
GRM5
HERC1
IP6K1
ITIH4
RASGRP1
TRMT61A

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 26 Oct 2026.

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