Genetic architecture of cytokine autoantibodies and associated risk of common diseases.

doi:10.1038/s41467-026-76394-7

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Article

Genetic architecture of cytokine autoantibodies and associated risk of common diseases.

Nature communications - 22 Aug 2026

von Stemann Jakob Hjorth, Dowsett Joseph, Teglgaard Rebecca Svanberg, Didriksen Maria, Pedersen Frederikke Byron, Bentsen Mette Skou, Barghetti Andrea, Laguarda Maria Vispe, Larsen Sara Louise Borregaard, Glintborg Bente, Lassen Ulrik, Frikke-Schmidt Ruth, Porsbjerg Celeste, Jensen Jens-Ulrik Stæhr, Werge Thomas, Schork Andrew J, Bundgaard Johan Skov, Bundgaard Henning, Hansen Torben, Bruun Mie Topholm, Aagaard Jensen Bitten, Mikkelsen Christina, Hartling Hans-Jakob, Erikstrup Christian, Pedersen Ole Birger, Sørensen Erik, Hansen Morten Bagge, Ostrowski Sisse Rye

Abstract excerpt

Anti-cytokine autoantibodies are increasingly recognized as modulators of immune function and determinants of disease risk, yet their genetic basis and population-level impact remain unclear. Here we perform genome-wide association studies of autoantibodies against IL-1α, IL-6, IL-10, IFN-α, IFN-β, IFN-γ and GM-CSF in 15,000 individuals from the Danish Blood Donor Study. We identify 52 genome-wide significant...

Read the complete abstract on PubMed

Topics

Humans
Autoantibodies
Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Cytokines

Genome-Wide Association Study

Arthritis, Rheumatoid

Genetic Risk Score

Female

Denmark

Neoplasms

Polymorphism, Single Nucleotide

Male

Risk Factors

Interleukin-6

Source

Open in PubMed Open full text

Identifiers

PMID: 42768006
DOI: 10.1038/s41467-026-76394-7
PMCID: PMC13594223

Provenance

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