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Article

Photobiomodulation Triggers M1/M2 Macrophage Polarization in Zymosan-Induced Acute Arthritis in Mice.

Journal of biophotonics - 1 Sept 2026

Ferreira Victória Batista, de Souza Álvaro Carneiro, Dos Anjos Lúcia Mara Januário, da Silva Ferreira Ana Caroline, da Silva Marcelle Abreu, de Souza da Fonseca Adenilson, de Paoli Flávia

Abstract excerpt

OBJECTIVE: To investigate whether photobiomodulation (PBM) modulates macrophage polarization in zymosan-induced acute joint inflammation, promoting an M1 to M2 phenotype shift. METHODS: Mice received intra-articular zymosan and PBM (830 nm, 10 mW) at 3 and 30 J/cm2. Euthanasia occurred at 24, 48, and 72 h. Polarization was assessed via mRNA levels and protein expression. RESULTS: At 24 h, both fluences...

Read the complete abstract on PubMed

Topics

Animals
Zymosan
Macrophages
Mice
Low-Level Light Therapy
Cell Polarity

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Arthritis

Acute Disease

Nitric Oxide Synthase Type II

Male

Phenotype

RNA, Messenger

Source

Identifiers

PMID: 42767265
DOI: 10.1002/jbio.70366

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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