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Article

Direct Current Electrical Stimulation Shifts THP-1-Derived Macrophage Polarization towards Pro-Regenerative M2 Phenotype.

International journal of molecular sciences - 2 Jul 2024

Bianconi Santiago, Leppik Liudmila, Oppermann Elsie, Marzi Ingo, Henrich Dirk

Abstract excerpt

A macrophage shift from the M1 to the M2 phenotype is relevant for promoting tissue repair and regeneration. In a previous in vivo study, we found that direct current (DC) electrical stimulation (EStim) increased the proportion of M2 macrophages in healing tissues and directed the balance of the injury response away from healing/scarring towards regeneration. These observations led us to hypothesize that DC EStim...

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Identifiers

PMID: 39000377
DOI: 10.3390/ijms25137272
PMCID: PMC11242703

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