Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Zhenwu Decoction Attenuates Water-Retention-Related Phenotypes and Multiorgan Injury in Rats With Doxorubicin-Induced Chronic Heart Failure.

Cardiovascular therapeutics - 1 Jan 2026

Li Weijun, Zhao Zhenyu, Lin Xuefeng, Chen Guoliang, Li Lin, Fang Ge, Hu Zhixi

Abstract excerpt

OBJECTIVE: This study is aimed at evaluating the effects of Zhenwu Decoction (ZWD) on cardiac dysfunction, water-retention-related phenotypes, and brain and kidney injury in rats with doxorubicin-induced chronic heart failure (CHF), and at examining whether these effects were accompanied by changes in AVP, V2R, PKA-Cα, and AQP2-related markers. METHODS: Rats that met the prespecified CHF criteria after...

Read the complete abstract on PubMed

Topics

Animals
Heart Failure
Doxorubicin
Drugs, Chinese Herbal
Aquaporin 2
Disease Models, Animal

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Kidney

Chronic Disease

Male

Phenotype

Receptors, Vasopressin

Rats, Sprague-Dawley

Arginine Vasopressin

Brain

Cyclic AMP-Dependent Protein Kinases

Myocardium

Ventricular Function, Left

Antidiuretic Hormone Receptor Antagonists

Source

Identifiers

PMID: 42764717
DOI: 10.1155/cdr/8444915

Genes

AQP2
AVP

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 28 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Zhenwu Decoction Attenuates Water-Retention-Related Phenotypes and Multiorgan Injury in Rats With Doxorubicin-Induced Chronic Heart Failure.PMID 42764717Read ↗

Clinical phenotypes according to diuretic combination in acute heart failure.Semantic proximity Read ↗

Transcriptomic Insights into Early Diagnosis of Doxorubicin-Induced Cardiotoxicity in a Rat ModelSemantic proximity Read ↗

Unleashing the cardioprotective potential of Ezetimibe against Doxorubicin-induced cardiotoxicity in Wistar rats: Targeting oxidative stress and NF-κB-mediated inflammationSemantic proximity Read ↗

PTEN inhibitor VO-OHpic attenuates inflammatory M1 macrophages and cardiac remodeling in doxorubicin-induced cardiomyopathy.Semantic proximity Read ↗

Myocardial protective effect and transcriptome profiling of Naoxintong on cardiomyopathy in zebrafishSemantic proximity Read ↗

Cyp1 Inhibition Prevents Doxorubicin-Induced Cardiomyopathy in a Zebrafish Heart-Failure Model.Semantic proximity Read ↗

Strategies for pharmacologic modulation of the heart failure phenotype.Semantic proximity Read ↗

Diuretic activity and mechanism of Mosla chinensis Maxim. cv. Jiangxiangru in normal RatsSemantic proximity Read ↗

Qishentaohong Granule as Adjuvant Therapy for Improving Cardiac Function and Quality of Life in Patients with Chronic Heart Failure: a Randomized Controlled TrialSemantic proximity Read ↗

The congestion “Pandemic” in Acute Heart Failure PatientsSemantic proximity Read ↗

Inhibition of late INa prevents pathological hyperactivation of CaMKIIδ in a murine model of acute Doxorubicin-related cardiocellular toxicitySemantic proximity Read ↗

Validation of HDAC8 Inhibitors as Drug Discovery Starting Points to Treat Acute Kidney InjurySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.