Genetic Causes of Thoracic Aortic Aneurysm: A Review.

Abstract excerpt

Thoracic aortic aneurysm (TAA) is an important cause of cardiovascular morbidity and mortality. TAA may occur due to inheritable genetic variants affecting the TGFβ signaling cascade, the extracellular matrix, or smooth muscle contraction, which are essential to maintain connective tissue homeostasis and vascular wall integrity. In this review, we summarize the available evidence on the genetics of thoracic...

Topics

• Humans
• Aortic Aneurysm, Thoracic
• Genetic Predisposition to Disease
• Risk Factors
• Phenotype
• Prognosis
• Heredity