Article
The Genetics of Thoracic Aortic Aneurysms and Dissection: A Clinical Perspective.
Biomolecules - 24 Jan 2020
Ostberg Nicolai P, Zafar Mohammad A, Ziganshin Bulat A, Elefteriades John A
Abstract excerpt
Thoracic aortic aneurysm and dissection (TAAD) affects many patients globally and has high mortality rates if undetected. Once thought to be solely a degenerative disease that afflicted the aorta due to high pressure and biomechanical stress, extensive investigation of the heritability and natural history of TAAD has shown a clear genetic basis for the disease. Here, we review both the cellular mechanisms and...
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