Integrative Multi-Omics Analysis Identifies Candidate MicroRNA Regulatory Networks Associated With High-Altitude Adaptation in Tibetan Pigs.

Abstract excerpt

MicroRNAs (miRNAs) are key posttranscriptional regulators of gene expression and play important roles in physiological responses to hypoxia, particularly in the cardiovascular system. However, the regulatory roles of miRNAs in cardiopulmonary tissues during high-altitude adaptation remain poorly understood. Tibetan pigs are a high-altitude-adapted breed with strong hypoxia tolerance, making them an ideal model...

Topics

• Animals
• MicroRNAs
• Altitude
• Sus scrofa
• Adaptation, Physiological
• Gene Regulatory Networks