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Article

Validation of next‑generation sequencing‑derived circulating mRNA variants as potential diagnostic tools in hepatocellular carcinoma and cholangiocarcinoma.

Oncology reports - 1 Nov 2026

Zezulinski Daniel, Hoteit Maarouf A, Kaplan David E, Zhan Tingting, Doria Cataldo, Block Timothy M, Sayeed Aejaz

Abstract excerpt

Liquid biopsy can transform oncology practice through early detection and real‑time monitoring of cancer progression and response to treatment. Circulating cell‑free tumor RNA offers promise as a novel and emerging alternative to circulating cell‑free tumor DNA for detecting the presence and understanding the biology of liver tumors. Both circulating DNA and RNA, which predominantly reside in extracellular...

Read the complete abstract on PubMed

Topics

Humans
Carcinoma, Hepatocellular
Liver Neoplasms
Cholangiocarcinoma
High-Throughput Nucleotide Sequencing

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Female

Biomarkers, Tumor

Male

Mutation

RNA, Messenger

Middle Aged

Bile Duct Neoplasms

Aged

Liquid Biopsy

Adult

Source

Open in PubMed Open full text

Identifiers

PMID: 42757462
DOI: 10.3892/or.2026.9196
PMCID: PMC13613964

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

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