Porphyromonas gingivalis outer membrane vesicles induce an activated but permissive neutrophil phenotype.

doi:10.3389/fimmu.2026.1896511

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Article

Porphyromonas gingivalis outer membrane vesicles induce an activated but permissive neutrophil phenotype.

Frontiers in immunology - 1 Jan 2026

Fretes Ailén, Lara Brenda, Calo Guillermina, Rojas Campión Ignacio, Materazzi Lourdes, Sabbione Florencia, Robaldi Stefania A, Pautasso Maria Constanza, Pérez Leirós Claudia, Vota Daiana, Tribelli Paula M, Hauk Vanesa

Abstract excerpt

Introduction: Porphyromonas gingivalis (Pg) is a keystone periodontal pathogen linked to adverse pregnancy outcomes that releases outer membrane vesicles (OMV) capable of modulating innate immune responses; however, whether PgOMV reprogram neutrophil antimicrobial and metabolic functions, and how the bacterial oxidative environment shapes these effects, remained unknown. Methods: To address this, we evaluated the...

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Topics

Humans
Porphyromonas gingivalis
Neutrophils
Neutrophil Activation
Oxidative Stress

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Female

Phenotype

Trophoblasts

Extracellular Traps

Pregnancy

Reactive Oxygen Species

Extracellular Vesicles

Bacterial Outer Membrane

Cell Movement

Bacteroidaceae Infections

Source

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Identifiers

PMID: 42755492
DOI: 10.3389/fimmu.2026.1896511
PMCID: PMC13581572

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