Article
Clinical phenotypes of ANCA-associated vasculitis using ensemble clustering: prognostic and therapeutic insights from two Japanese cohorts.
Rheumatology (Oxford, England) - 1 Sept 2026
Inoue Hironori, Kida Takashi, Fujioka Kazuki, Omura Satoshi, Yanagida Takuya, Shimada Yuki, Kitai Junya, Seno Takahiro, Kohno Masataka, Nakagomi Daiki, Abe Yoshiyuki, Wada Makoto, Takizawa Naoho, Nomura Atsushi, Kukida Yuji, Kondo Naoya, Takagi Hirosuke, Endo Koji, Hirata Shintaro, Azuma Naoto, Takeuchi Tohru, Fukui Shoichi, Kamada Kazuro, Yanai Ryo, Matsuo Yusuke, Shimojima Yasuhiro, Nishioka Ryo, Okazaki Ryota, Takata Tomoaki, Moriyama Mayuko, Takatani Ayuko, Miyawaki Yoshia, Shirai Tsuyoshi, Dobashi Hiroaki, Ito Takafumi, Matsumoto Isao, Takada Toshihiko, Ito-Ihara Toshiko, Yajima Nobuyuki, Kawaguchi Takashi, Ikeuchi Hidekazu, Nakaya Izaya, Shimoyama Kumiko, Amano Koichi, Endo Tomomi, Ushio Yusuke, Komagata Yoshinori, Naniwa Taio, Kawakami Atsushi, Higuchi Tomoaki, Nagasaka Kenji, Uchida Haruhito A, Tamura Naoto, Kawahito Yutaka
Abstract excerpt
OBJECTIVES: Clinical heterogeneity in ANCA-associated vasculitis (AAV) is not fully captured by conventional disease subtypes or ANCA serotypes. We aimed to identify data-driven, clinically meaningful disease phenotypes based on patterns of organ involvement in microscopic polyangiitis (MPA) and granulomatosis with polyangiitis (GPA), and to evaluate their prognostic and therapeutic implications. METHODS: We...
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