Article
Phenotype, serotype, and data-driven clustering reveal complementary dimensions of heterogeneity in ANCA-associated vasculitis: a multicentre Japanese cohort (J-CANVAS).
Rheumatology international - 12 Nov 2025
Kidoguchi Genki, Yoshida Yusuke, Omura Satoshi, Nakagomi Daiki, Abe Yoshiyuki, Wada Makoto, Takizawa Naoho, Nomura Atsushi, Kukida Yuji, Kondo Naoya, Takagi Hirosuke, Endo Koji, Azuma Naoto, Takeuchi Tohru, Fukui Shoichi, Kamada Kazuro, Yanai Ryo, Matsuo Yusuke, Shimojima Yasuhiro, Nishioka Ryo, Okazaki Ryota, Takata Tomoaki, Moriyama Mayuko, Takatani Ayuko, Miyawaki Yoshia, Shirai Tsuyoshi, Dobashi Hiroaki, Ito Takafumi, Matsumoto Isao, Takada Toshihiko, Kawahito Yutaka, Ito-Ihara Toshiko, Kida Takashi, Yajima Nobuyuki, Kawaguchi Takashi, Hirata Shintaro
Abstract excerpt
OBJECTIVE: To compare clinicopathological phenotype-based, anti-neutrophil cytoplasmic antibody (ANCA) serotype-based, and unsupervised data-driven classifications in relation to clinical outcomes and patient heterogeneity in a large Japanese cohort with ANCA-associated vasculitis (AAV). METHODS: This multicentre, retrospective cohort study analysed data from a nationwide Japanese registry of 729 newly diagnosed...
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- Humans
- Female