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Article

Distinct phenotypic clusters associated with progressive pulmonary fibrosis in anti-synthetase syndrome-associated interstitial lung disease.

Frontiers in immunology - 1 Jan 2026

Gao Zongshuai, Zhu Yunxia

Abstract excerpt

Background: The clinical manifestations of anti-synthetase syndrome-associated interstitial lung disease (ASyS-ILD) are highly heterogeneous, and the mechanisms underlying its development and progression remain poorly understood. This study aimed to identify distinct clinical phenotypes of ASyS-ILD and clusters associated with progressive pulmonary fibrosis (PPF) using unsupervised cluster analysis. Methods: A...

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Identifiers

PMID: 42661877
DOI: 10.3389/fimmu.2026.1899365
PMCID: PMC13518561

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