Article
Evolutionary Insights of Hepatitis B Virus Genotypes and Profiles of Mutations in Surface and Basal Core Promoter/Pre-Core Genes Among HBsAg-Positive Patients in North-Central and Southwestern Nigeria.
Viruses - 10 Aug 2025
Abechi Priscilla, George Uwem E, Adejumobi Olawale A, Ahmad Umar, Aborisade Olamide Y, Oragwa Arthur O, Ajayi Oluremi I, Akinlo Oluwasemilogo O, Happi Christian, Folarin Onikepe A
Abstract excerpt
In Nigeria, hepatitis B virus (HBV) infection remains a significant public health issue. The emergence of immune escape mutants (IEMs), basal core promoters, and precore (BCP/PC) mutants among asymptomatic individuals has enabled the continuous evolution of the virus in the country. In this study, we used Sanger sequencing of the S gene and the BCP/PC region to investigate the genetic diversity, phylogenetic...
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