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Article

Genomic and functional analysis of rmp locus variants in Klebsiella pneumoniae.

Genome medicine - 9 Apr 2025

Lam Margaret M C, Salisbury Stephen M, Treat Logan P, Wick Ryan R, Judd Louise M, Wyres Kelly L, Brisse Sylvain, Walker Kimberly A, Miller Virginia L, Holt Kathryn E

Abstract excerpt

BACKGROUND: Klebsiella pneumoniae is an opportunistic pathogen and a leading cause of healthcare-associated infections in hospitals, which are frequently antimicrobial resistant (AMR). Exacerbating the public health threat posed by K. pneumoniae, some strains also harbour additional hypervirulence determinants typically acquired via mobile genetic elements such as the well-characterised large virulence plasmid...

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Identifiers

PMID: 40205597
DOI: 10.1186/s13073-025-01461-5
PMCID: PMC11984045

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