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Article

A preeclampsia prediction model incorporating methylenetetrahydrofolate reductase, vitamin D receptor, and uterine artery pulsatility index.

Hypertension in pregnancy - 31 Dec 2026

Xu Mei, Yang Ge, Zhong XingBo, Jin Zhao, Tang MingQiang, Xiao Yu, Guo YongCan

Abstract excerpt

OBJECTIVE: This study evaluated the predictive value of methylenetetrahydrofolate reductase (MTHFR) rs1801133 and vitamin D receptor (VDR) FokI rs2228570 polymorphisms combined with uterine artery pulsatility index (PI) for preeclampsia (PE), and explored mediating pathways underlying genetic risk. METHODS: A two-phase prospective study was conducted. Phase I (n = 73) screened PE-related single nucleotide...

Read the complete abstract on PubMed

Topics

Humans

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Female

Methylenetetrahydrofolate Reductase (NADPH2)

Pregnancy

Pre-Eclampsia

Uterine Artery

Receptors, Calcitriol

Polymorphism, Single Nucleotide

Pulsatile Flow

Adult

Prospective Studies

Nomograms

Source

Identifiers

PMID: 42723529
DOI: 10.1080/10641955.2026.2719500

Genes

MTHFR
VDR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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