PD-L1 Tumour-Cell/Immune-Cell Phenotype, Early Nodal Status and Serum Biomarkers in Locally Advanced Head and Neck Squamous Cell Carcinoma Receiving Neoadjuvant Therapy: A Retrospective Cohort Study With Exploratory Survival Analysis.

doi:10.1002/cam4.72205

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PD-L1 Tumour-Cell/Immune-Cell Phenotype, Early Nodal Status and Serum Biomarkers in Locally Advanced Head and Neck Squamous Cell Carcinoma Receiving Neoadjuvant Therapy: A Retrospective Cohort Study With Exploratory Survival Analysis.

Cancer medicine - 1 Sept 2026

Wang Ningning, Yun Zehui, Cao Fangli

Abstract excerpt

PD-L1 tumour-cell (TC) and immune-cell (IC) expression are scored separately in head and neck squamous cell carcinoma (HNSCC) but are often collapsed into a combined positive score, potentially obscuring distinct patterns. In this retrospective, single-centre cohort of 61 patients with locally advanced, hypopharynx-predominant HNSCC receiving neoadjuvant chemoimmunotherapy (n = 46) or chemotherapy alone (n = 15),...

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Topics

Humans
Neoadjuvant Therapy
Retrospective Studies
B7-H1 Antigen
Female
Biomarkers, Tumor

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Male

Squamous Cell Carcinoma of Head and Neck

Head and Neck Neoplasms

Middle Aged

Phenotype

Aged

Lymphatic Metastasis

Adult

Survival Analysis

Source

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Identifiers

PMID: 42711956
DOI: 10.1002/cam4.72205
PMCID: PMC13554422

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