Article
Social disconnection integrates genetic and proteomic risks in suicidal ideation and depression.
Translational psychiatry - 7 Sept 2026
Li Sihong, Huang Zhongting, Chen Hui, Chen Xianliang, Tang Huajia, Ye Yanyue, Zhu Jijun, Wang Shenghan, Li Pan, Zhang Shunjie, Zhuang Haowen, Liu Weixin, Cai Fuqiang, Song Zhijian, Liu Yuxin, Zhou Jiansong, Chen Junfang
Abstract excerpt
Suicidal ideation (SI) and major depressive disorder (MDD) are complex psychiatric conditions arising from the interplay of genetic liability, molecular processes, and psychosocial factors. While these dimensions have been extensively studied in isolation, their joint contribution to SI and MDD remains unclear. This study integrates multi-modal data to elucidate these synergistic effects and develop robust models...
Read the complete abstract on PubMedTopics
- Humans
- Suicidal Ideation
- Major Depressive Disorder
- Proteomics
- Female