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Article

Causal associations between inflammatory bowel disease and sepsis: a two-sample Mendelian randomization study.

BMC medical genomics - 17 Apr 2025

Tong Renyang, Liang Ziting, Zhuo Chengui, Bai Xueyang, Dao Ling, Yu Lu, Li Ling, Tong Zhaohui, Du Youyou, Xu Longwei

Abstract excerpt

BACKGROUND: Recent observational studies have revealed an inconclusive correlation between inflammatory bowel disease (IBD) and sepsis, accompanied by an uncertain understanding of the causal relationship between the two. To investigate the causality between IBD and sepsis, we employed a two-sample Mendelian randomization (MR) approach. METHODS: A genome-wide significant threshold (P < 5 × 10-8) was achieved in...

Read the complete abstract on PubMed

Topics

Humans
Mendelian Randomization Analysis
Sepsis
Polymorphism, Single Nucleotide
Inflammatory Bowel Diseases
Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Crohn Disease

Genome-Wide Association Study

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Identifiers

PMID: 40247302
DOI: 10.1186/s12920-025-02143-2
PMCID: PMC12004876

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