Next Generation Sequencing for the Differentiation of Benign and Malignant Biliary Strictures.

doi:10.1111/liv.70865

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Article

Next Generation Sequencing for the Differentiation of Benign and Malignant Biliary Strictures.

Liver international : official journal of the International Association for the Study of the Liver - 1 Oct 2026

Gillmeister Antonia, Husman Julia, Schmelz Renate, Brückner Stefan, Hampe Jochen, Aust Daniela, Zeissig Sebastian

Abstract excerpt

The differentiation between benign and malignant biliary strictures remains a significant clinical challenge. Recent studies have suggested that next generation sequencing (NGS) can improve the diagnostic accuracy. However, evidence on its performance in routine clinical practice is limited. Therefore, validation of the diagnostic value of NGS using real-world clinical data is warranted. We compared the...

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Topics

Humans
High-Throughput Nucleotide Sequencing
Bile Duct Neoplasms
Cholangiocarcinoma
Diagnosis, Differential

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Cholestasis

Mutation

Sensitivity and Specificity

Cholangiopancreatography, Endoscopic Retrograde

Constriction, Pathologic

CA-19-9 Antigen

Bile Ducts, Intrahepatic

Biopsy

Female

Source

Open in PubMed Open full text

Identifiers

PMID: 42698384
DOI: 10.1111/liv.70865
PMCID: PMC13545652

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