Article
The FADS insertion-deletion polymorphism drives the arachidonic acid/dihomo-gamma-linolenic acid ratio in preterm infants and may contribute to patency of ductus arteriosus - a pilot study.
Prostaglandins, leukotrienes, and essential fatty acids - 1 Oct 2026
Herrman Kristy, Reid Davika, Li Yan Ning, Park Hui Gyu, Mukherjee Priya, Brand Kathryn, Gonzales Jennifer, Kothapalli Kumar, Brenna J T
Abstract excerpt
BACKGROUND: The FADS Indel insertion-deletion polymorphism (rs66698963) modulates fatty acid desaturase 1 (FADS1), which converts di-homo-γ-linolenic acid (DGLA) to arachidonic acid (ARA). Adults homozygous for the I allele (I/I) have up to 84% higher ARA/DGLA ratios than D homozygotes (D/D), with heterozygotes intermediate. Whether this relationship extends to preterm neonates is unknown. ARA is the precursor to...
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- Humans
- Infant, Newborn
- Pilot Projects